If you continue browsing the site, you agree to the use of cookies on this website. Ppt giant cell tumor of bone powerpoint presentation free to download id. In a previous publication i 1 suggested the use of the terms benign giantcell tumor and malignant giantcell sarcoma in an attempt to clarify the differentiation. Pdf a recurrent giant cell tumor of bone treated with. A giant cell tumor of bone is a type of benign noncancerous tumor that typically occurs in young adults between the ages of 20 and 40. Giant cell tumor of the temporal bone a case report. Introduction it is one of the most common bone tumors encountered.
Chief complaints of left thigh and knee pain since 6 months. Intensity modulated radiotherapy imrt in benign giant. Giant cell tumor of bone gctb first described by cooper and travers in 1818 1. Malignancy in giantcell tumor is uncommon and occurs in about 2% of all cases.
As a result of reading this article, physicians should be able to. Giant cell tumor gct of bone is a locally destructive tumor that occurs predominantly in long bones of postpubertal adolescents and young adults, where it occurs in the epiphysis. A giant cell tumor gct is an osteolytic tumor believed to originate from. Giant cell tumor of bone is a rare, fastgrowing noncancer tumor. The location of a giant cell tumor is often in the knee, but can also. Giant cell tumor free download as powerpoint presentation. Anzawa u, hanaoka h, shiraishi t, morioka h, morii t, toyama y.
Although surgical treatment resulted in many cures of patients who had these tumors, i became wary in my prognosis for i found that occasionally there was recurrence of the. Giant cell tumor health encyclopedia university of. The authors, however, do not mention the role of metabolic imaging with fluorodeoxyglucose f 18 18 ffdg positron emission tomographycomputed tomography scans petct in the diagnosis of this disease. They mostly occur in the long bones found in the arms and legs. The rank pathway is often reported to be involved in the pathogenesis of giant cell tumor of bone.
Commonly found in long bones such as proximal tibia and distal femur. A giant cell tumour of the bone is a rare, noncancerous, tumour commonly. Giant cell tumors are rare neoplasms, representing less than 5% of all bone tumors. Pdf giant cell tumor gct of bone is a locally aggressive benign neoplasm that is associated with a large. However, a small percentage occurs in pelvis, spine or skull bones, where complete resection is challenging. Ppt giant cell tumor of bone powerpoint presentation. The erosion of the bone associated with giant cell tumors is due to pressure on the bone and not due to the invasion of the bone by the tumor. Although rarely lethal, benign bone tumors may be associated with a substantial disturbance of the local bony architecture that can be particularly troublesome in periarticular locations. Files are available under licenses specified on their description page. They are always found at the end of the bone next to the joint.
Pdf giant cell tumor gct of bone is generally a benign tumor composed of mononuclear stromal cells and characteristic multinucleated. Benign but locally aggressive primary bone neoplasm composed of mononuclear round to spindle cells with numerous evenly dispersed osteoclastlike giant cells. The adobe flash plugin is needed to view this content. The tumor is composed of giant multinucleated cells osteoclastlike cells, mononuclear macrophages, and mononuclear stromal cells which secrete promyeloid and pro. Pdf giant cell tumor of bone revisited researchgate. Definition of bone, giant cell tumor of medicinenet. Metastasis, with identical morphology to the primary tumor, occurs in a few percent. Cooper in 1818 first described giant cell tumors gct of the bone 1. First recognized in 1818 1, it was not until 1940 that gctb was formally distinguished from other tumors of bone, such as aneurysmal bone cyst, chondroblastoma, and nonossifying fibroma 2. Patients usually present with pain and limited range of motion caused by tumors proximity to the joint space.
Probability of remaining free of recurrence, based on ennekings surgical stage. Giant cell tumours of the bone make up 45% of all primary tumours which start in the bone. For a downloadable source of this information, please view our downloadable. The us food and drug administration fda today expanded the approved use of denosumab xgeva, amgen to include the treatment of adults and some adolescents with giant cell tumor of the bone.
Giant cell tumor of bone 1 giant cell tumor of bone 2 overview. Risk factors for recurrence and mean recurrence free survival was calculated using. This pathway is a key signaling pathway of bone remodeling that plays a critical role in differentiation of precursors into multinucleated osteoclasts, and activation of osteoclasts leading to bone resorption 32. Giant cell tumor of bone is very rarely seen in children or in adults older than 65 years of age. Although the recurrence rate of giant cell tumors of bone gctb is relatively high exact data on treatment options for the recurrent cases is lacking. Not the same tumor as giant cell lesion of the small bones. Of 327 patients who had a giantcell tumor of bone and were seen at the istituto rizzoli, 293 were t. Identify atrisk populations for giant cell tumor of bone. Pdf pulmonary metastases of giant cell tumor of the bone. Two hundred and fourteen patients with histologically certified gctb have been treated at the authors department from 1980 to 2007. Giant cell tumor gct of bone is a benign but aggressive bone tumor originating from mesenchymal cells.
Giant cell tumor of bone is an osseous neoplasm that is histologically benign but clinically shows local aggression and high rate of recurrence. However, for unknown reasons, this tumour occurs 2 to 3 times more often in southern india and china where giant cell tumours of the bone make up a much larger 20% of all primary bone tumour cases1,3 some reports show a higher number of giant cell tumour of the bone cases in female patients than. He presented with right side severe hearing loss and. We aim to provide unbiased information free from any commercial conflicts of interest. Giantcell tumor of the bone gctob, is a relatively uncommon tumor of the bone. A tumor of bone characterized by massive destruction of the end epiphysis of a long bone. Giant cell tumours of the bone make up approximately 45% of all tumours. Giant cell tumor of bone an overview abstract giant cell tumors gct are benign tumors with potential for aggressive behavior and capacity to metastasize. Though benign tumor, it is locally aggressive and has malignant potential they have significant bone destruction,local recurrence and occasional metastasis 3. Giant cell tumor of bone genetic and rare diseases. The vast majority of giant cell tumors occurs in extremity sites and is treated by surgery alone. While a giant cell tumor can occur in any bone, it is most commonly located in the metaphysis or at the end epiphysis of the thigh bone femur or shin bone tibia. Most often, the tumors occur close to the knee jointat the lower end of the thighbone femur or the upper end of the shinbone tibia. Local recurrence of giant cell tumor of bone after intralesional treatment with and without adjuvant therapy.
Their local aggressiveness explained by later nelaton and malignant features showed by virchow 2,3. Giant cell tumor of bone with secondary aneurysmal bone cyst. It causes pain, restricts movement, and is usually cancerous. Although they are benign, gct can grow fast and damage the affected bone and spread to the soft tissue around it. It usually grows near a joint at the end of the bone. However, if malignant degeneration does occur, it is likely to metastasize to the lungs. The petrous portion of the temporal bone forms a rare location for this tumor. Disease bioinformatics research of giant cell tumor of bone has been linked to neoplasms, bone neoplasms, giant cell tumors, malignant paraganglionic neoplasm, neoplasm metastasis. Giant cell tumor gct of bone is one of the commonest benign bone tumors encountered by an orthopedic surgeon.
Patient education giant cell tumor center for foot. It most often grows in adults between ages 20 and 40 when skeletal bone growth is done. In addition to wide excision, preservation of ankle. A favorable clinical outcome is expected when the tumor is excised to tumorfree margins, however. Radiation therapy seems to be an option in these patients, despite the lack of a generally accepted. The excised bone gap needs reconstruction using tricortical iliac autograft and supportive plate fixation. Gct mostly affects people between the ages of 20 and 30 years old. Wide excision or intralesional curettage, along with adjuvant chemical cauterisation can prevent the recurrence of gct. Giant cell tumour gct of the distal fibula is extremely rare and poses challenges in the surgical management. Giant cell tumors gct are benign tumors with potential for aggressive behavior and capacity to metastasize. Treatment and recurrence of giant cell tumors of bone a. The authors report a case of a large giant cell tumor involving the petrous and squamous portions of the temporal bone in a 26 year old male patient. It generally occurs in adults between the ages of 20 and 40 years. Giant cell tumor of bone gct is a rare, aggressive noncancerous tumor.
Giant cell tumor of bone list of high impact articles. Giant cell tumor is one of the more common benign bone. The study of giant cell tumor of bone has been mentioned in research publications which can be found using our bioinformatics tool below. Giant cell tumor of bone 1 authorstream presentation. Giant cell tumours gct are benign noncancerous tumours that develop in the bone. A rare bone sarcoma characterized by a usually benign spaceoccupying lesion, which is nevertheless locally aggressive and massively damaging to surrounding bone tissue. H3f3a mutation detection can be used as a diagnostic tool for the distinction of giant cell tumor of bone from other giant cellcontaining tumors. All structured data from the file and property namespaces is available under the creative commons cc0 license. A subset of the mutations can be easily detected using a g34w mutation specific antibody. Giant cell tumor gct of bone is a locally aggressive benign neoplasm that is associated with a large biological spectrum ranging from latent benign to highly recurrent and occasionally. Giant cell tumor of bone dr milind merchant slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising.
Vascular invasion outside the boundary of the tumor can be seen. Treatment options for recurrent giant cell tumors of bone. Giant cell tumor gct of bone is generally a benign tumor. Similarities between giant cell tumor of bone, giant cell tumor of tendon sheath, and pigmented villonodular synovitis concerning ultrastructural cytochemical features of. The majority are treated by aggressive curettage or resection. Giant cell tumor of bone gctb is a relatively rare, benign, but locally aggressive osteolytic skeletal neoplasm of young adults. Giant cell tumor of bone gct is a destructive and potentially metastatic bone tumour in which the characteristic giant cells have classically been considered the culprits in bone destruction. Recognize the biology that drives giant cell tumor of bone. Tumor surgery tumor education bone tumors types of. Columbia university, new york classification secondary metastases 95% primary 5% 2 secondary tumors.
Introduction giant cell tumor gct is a bone tumor involving epiphyseal area of bone abutting the subchondral bone. The authors present data that purports a predictive value to vegf expression in giant cell tumor of bone supported by a correlation between the levels of vegf expression and. Other common soft tissues masses that may occur in the foot are ganglions, fibromas. It is characterized by the presence of multinucleated giant cells osteoclastlike cells. It accounts for 410% of all bone tumors and typically affects the metaepiphyseal region of long bones of young. Giant cell tumor is a benign but locally aggressive bone neoplasm which uncommonly involves the skull. Giant cell tumour of the bone bone cancer research trust. Initially, described by cooper and travers in 1818 as an aggressive and destructive lesion of long bones, then virchow first described the recurrence and possible degeneration into a malignant gct. Giant cell tumor of bone gpn banff pathology course. The possible surgical procedures range from repeated intralesional curettage to wide resection. The reported incidence of gct in the oriental and asian population is higher than that in the caucasian population and may account for 20% of all skeletal neoplasms.
The diagnosis of a giant cell tumor is generally made by a pathologist following removal of the mass. Morphological and immunophenotypic features of primary and metastatic giant cell tumour of bone. The site most commonly struck by this tumor is the knee the far end of the femur and the near end of the tibia. Webpathology is a free educational resource with 10328 high quality pathology images of benign and malignant neoplasms and related entities. Giant cell tumor gct of the bone is one of the rare benign, primary, bone. Abstract giant cell tumor gct of bone is a locally aggressive benign neoplasm that is associated with a large biological spectrum ranging from latent benign to highly recurrent and occasionally metastatic malignant bone tumor. Giant cell tumor orthopaedicsone articles orthopaedicsone. This video presentation briefly explains the diagnosis and treatment of the giant cell tumor of the bone. Zheng mh, fan y, panicker a, et al detection of mrnas for urokinasetype plasminogen activator, its receptor, and type 1 inhibitor in giant cell tumors of bone with in situ hybridization.
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